Noninvasive real-time measurement of nasal mucociliary clearance in mice by pinhole gamma scintigraphy
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چکیده
منابع مشابه
Noninvasive real-time measurement of nasal mucociliary clearance in mice by pinhole gamma scintigraphy.
Mucociliary clearance (MCC) is the key defense mechanism in the upper airways, as the removal of debris-laden mucus in the sinuses completely depends on MCC. So far, how the nasal MCC is regulated remains unknown. Recently, mice deficient in genes encoding the components of MCC apparatus have been generated, which will allow investigators to conduct more in-depth nasal MCC studies. However, the...
متن کاملMeasurement of nasal mucociliary clearance.
The saccharin test was carried out in a randomly selected sample of schoolchildren (142 boys and 153 girls, age range 11-14 years) to determine the variability and reproducibility of the test and to assess whether it could be used as a screening test for nasal mucociliary clearance. Nasal mucociliary clearance times were analysed according to clinical history (asthma, rhinitis, asthma with rhin...
متن کاملMeasurement of Nasal Mucociliary Clearance
Mucociliary clearance (MCC), a vital key defense mechanism is especially important in the upper airways and sinuses, as it protects the body against noxious inhaled materials [1]. The removal of debris-laden mucus in the sinuses completely depends on MCC, whereas in the lower airways, MCC can be compensated for by other mechanisms like coughing [2]. The nasal mucociliary clearance (NMC) system ...
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The nasal cavity possesses many advantages as a site for drug delivery, such as, ease of administration, applicability for long term treatments and a large surface area for absorption. One important limiting factor for nasal drug delivery is the limited time available for absorption within the nasal cavity due to mucociliary clearance. Several drug delivery systems including different kinds of ...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2010
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00669.2009